Don't flush prescription drugs down the toilet or pour them right into a drain Except instructed to take action. Properly discard this solution when it can be expired or now not necessary. Speak to your pharmacist or community squander disposal firm.

Your Health care provider may well do blood exams to look for adrenal gland difficulties. Simply call your healthcare provider straight away When you have any of these signs and symptoms:

Rinse out the measuring machine Once you have a dose of promethazine/codeine to make sure any residual medicine is washed out.

Promethazine is commonly distributed in body tissues. Promethazine has high protein binding with about 80 to 93% of promethazine certain to plasma proteins. Promethazine passes the blood Mind barrier and also the placental barrier.

Because of very similar pharmacologic properties, it truly is sensible to expect similar risk with concomitant usage of opioid cough medicines and benzodiazepines, other CNS depressants, or Alcoholic beverages.

Promethazine is surely an H1 receptor blocking agent. In addition to its antihistaminic action, it offers clinically handy sedative and antiemetic consequences.

DailyMed will produce this notification towards your desktop, Web browser, or e-mail depending on the RSS Reader you select to employ. To look at current drug label hyperlinks, paste the RSS feed tackle (URL) proven down below right into a RSS reader, or make use of a browser which supports RSS feeds, for instance Safari for Mac OS X.

, ritonavir) or discontinuation of a cytochrome P450 3A4 inducer including rifampin, carbamazepine, and phenytoin, might bring about a rise in codeine plasma concentrations with subsequently better metabolism by cytochrome P450 2D6, causing bigger morphine stages, which could boost or lengthen adverse reactions and should trigger likely deadly respiratory depression.

Due to the hazards of habit, abuse, and misuse with opioids, even at suggested doses, reserve Promethazine HCl and Codeine Phosphate Oral Resolution more info to be used in Grownup individuals for whom the many benefits of cough suppression are anticipated to outweigh the dangers, and in whom an enough assessment in the etiology with the cough has been made.

We’d choose to established more cookies to know how you utilize GOV.UK, keep in mind your settings and improve governing administration products and services.

Blockage on the Gut. A lot of people using promethazine/codeine may here well produce serious constipation or simply a blockage with the intestine (bowel obstruction). Halt using promethazine/codeine and call your website healthcare supplier right away When you have any of the subsequent signs and symptoms of the blockage in your intestines.

Make sure individuals have an oral dosing dispenser that actions here the suitable quantity in milliliters. Counsel sufferers regarding how to use an oral dosing dispenser and correctly measure the oral suspension as prescribed.

Young children Postmarketing conditions of respiratory despair, such as fatalities, are already described with usage of promethazine in pediatric patients. Concomitant administration with other respiratory depressants might raise the possibility of respiratory despair.

Codeine has been noted to indicate no evidence of carcinogenicity or mutagenicity in here a variety of check devices, such as the micronucleus and sperm abnormality assays and the Salmonella assay. Promethazine was nonmutagenic while in the Salmonella test program of Ames.